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KMID : 0882420110800050553
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Korean Journal of Medicine
2011 Volume.80 No. 5 p.553 ~ p.561
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Clinical Differences According to Genotype in Acute Viral Hepatitis A in Daejeon, Korea
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Lee Young-Woo
Yang Hyeon-Woong
Lee Jin-A
Yun Ki-Ho
Yang Seong-Eun
Lee Min-Ji
Park Se-Young
Kim Sae-Hee
Lee Hyang-Ie
Lee Yun-Jung
Jung Sung-Hee
Kim An-Na
Cha Sang-Woo
Kim Soo-Young
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Abstract
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Background/Aims:Acute viral hepatitis A is a major health problem in Korea and the influx of genotype IIIA is thought to be one reason. We examined the differences in the clinical characteristics and laboratory findings of genotypes IA and IIIA in Daejeon.
Methods:From November 2009 to June 2010, 81 patients positive for IgM anti-HAV were enrolled prospectively. The hepatitis A was genotyped using real-time polymerase chain reaction. The clinical characteristics and laboratory results were compared on the basis of genotype.
Results:The mean patient age was 32.6 ± 7.4 years. The mean hospitalization was 7.7 ± 2.4 days. The patient occupation varied. Clinically, vomiting and diarrhea were relatively more prevalent in genotype IIIA than in IA. Abdominal pain and skin spots were relatively more prevalent in genotype IA than in IIIA. The hemoglobin, peak aspartate aminotransferase (AST) level, and C-reactive protein were statistically higher in genotype IIIA than in IA. The distributions of the peak AST, alanine aminotransferase (ALT) and total bilirubin values tended to be perched in genotype IIIA than in IA. The international normalized ratio (INR) tended to be slightly prolonged in genotype IIIA than in IA.
Conclusions: Recently, genotype IIIA of acute viral hepatitis A has become prevalent in Daejeon. Hepatitis A genotype IIIA probably causes worse laboratory abnormalities than genotype IA. (Korean J Med 2011;80:553-561)
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KEYWORD
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Hepatitis A, Prevalence, Genotype
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